There are seven candidates taking part in the contest.
Counting of the votes will take place on Thursday night after the close of polls.
The candidates Denise Baykal - UK Independence Party.
Dave Dempsey - Scottish Conservatives.
Stuart Graham - The Victims Final Right Party.
Jade Holden - Scottish Liberal Democrats.
Natalie McGarry - Scottish National Party.
Alex Rowley - Scottish Labour.
James Trolland - Scottish Democratic Alliance.
The result BBC Scotland will provide live coverage of the result online after 22.00.
There will also be a Newsnight Scotland by-election special on BBC2 Scotland, starting at 23:00.
Cowdenbeath By-Election - Winning Party (Bets taken) #LABOUR 1/16 (67.4%) #SNP 7/1 (32.6%) 100/1 BAR @sharpeangle (@Oddschecker )
— General Election (@UKELECTIONS2015) January 23, 2014